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Centralization of Esophagectomy: How Far Should We Go?
This study was designed to define a statistically sound and clinically meaningful cutoff point for annual hospital volume for esophagectomy. Higher hospital volumes are associated with improved outcomes after esophagectomy. However, reported optimal volumes in literature vary, and minimal volume standards in different countries show considerable variation. So far, there has been no research on the...
Use of cancer registries for public health & clinical research in Europe
To provide insight into cancer registration coverage, data access and use in Europe. A study was performed which contributes to data and infrastructure harmonisation and will foster a more prominent role of cancer registries (CRs) within public health, clinical policy and cancer research, whether within or outside the European Research Area.
Centralizing pancreatic cancer surgery: impact on resection and survival
In pancreatic surgery, the relationship between volume and postoperative mortality has become indisputable. The current study by G.A. Gooiker and colleagues investigated the impact of nationwide centralization of pancreatic surgery on resection rates and long-term survival.
No prognostic value of family history in urinary bladder cancer
First-degree relatives of urinary bladder cancer (UBC) patients have a twofold increased risk to develop UBC themselves. However, the impact of a positive family history on UBC prognosis is unknown. Therefore Egbers and colleagues compared the tumor characteristics and prognosis of UBC patients with a positive and negative UBC family history - the first ever such investigation.
Colorectal cancer & diabetes: effects on QoL and sexual function
This study examined the individual and combined effect of having colorectal cancer (CRC) and diabetes mellitus (DM) on health-related quality of life (HRQoL) and sexual functioning. Data on HRQoL and sexual functioning was collected within the PROFILES registry and linked to clinical data from the Eindhoven Cancer Registry.
Colon cancer: more often laparoscopy in high socioeconomic status
Patients with colon cancer with high socioeconomic status are more likely to be operated by laparoscopy compared to patients with low socioeconomic status. Furthermore, patients with high socioeconomic status are less likely to have a conversion to open surgery or developing anastomotic leakage or abcess. Patients with a high socioeconomic status are less likely to die within 30 days after surgery...
No effect of smoking cessation on bladder cancer prognosis
Cigarette smoking is the most important risk factor for urinary bladder cancer. The prognostic effect of cigarette smoking on disease recurrence and progression in patients with non-muscle-invasive bladder cancer (NMIBC), however, is still unclear. Therefore, Grotenhuis and colleagues evaluated the effect of smoking status and intensity, and timing of smoking cessation, on NMIBC prognosis. Based o...
Cytoprotective role of scalp cooling confirmed in in-vitro models
Cooling of cultured human keratinocytes at 22įC markedly reduced or completely inhibited cytotoxicity of docetaxel, adriamycine or cyclophosphamide. The level of temperature may be critical in rescuing cells, which stresses again the importance of clinical research on scalp skin temperature during scalp cooling. This was concluded by researchers from the UK and M. Komen (MC Alkmaar) and Corina van...
Examination of re-excision specimens of completely excised melanomas
The Dutch melanoma guideline advises to examine one central block of the re-excision scar in case of a complete primary excision. To increase the evidence for this recommendation, de Waal and collaegues re-evaluated how often residual melanoma was found in re-excision specimens of a large series of completely excised melanomas. They found that in only 0.5% of cases residual melanoma was detected. ...
Conditional survival for long-term colorectal cancer survivors
This study shows that the prognosis for colorectal cancer survivors improves with each additional year survived, with the largest improvements in the first years after diagnosis. Although colon cancer patients have a better prognosis compared to rectal cancer patients, the difference in conditional 5-year relative survival between colon and rectal cancer disappeared for all patients, except for st...
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