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No improvement in survival for patients with metastatic gastric cancer
The population based study of Bernards et al. showed that an increasing proportion of gastric cancer patients presents with metastatic disease. Despite the increased prescription of palliative chemotherapy and the presumed stage migration the overall survival of patients with metastatic gastric cancer did not change over time (1990-2011). A subgroup of patients might benefit from palliative chemot...
Changes in body weight during chemotherapy in breast cancer patients
Weight gain is a common problem for breast cancer patients treated with chemotherapy, having a negative impact on prognosis. Body weight information in 483 breast cancer patients showed a median weight gain of 6 kg during chemotherapy. There was more weight gain among patients treated with anthracyclines + taxanes than among patients treated with anthracyclines-only. This is partly explained by th...
Adjuvant chemotherapy in stage III mucinous colorectal carcinoma
NIJMEGEN / EINDHOVEN - Colorectal mucinous adenocarcinoma (MC) is associated with a poorer prognosis compared to patients with nonmucinous adenocarcinoma (NMC). Research of Niek Hugen (Radboudumc) in collaboration with researchers of the Eindhoven cancer registry showed that the poor prognosis for MC is only present in rectal cancer. In the adjuvant setting, there is no difference in the efficacy ...
Metachronous peritoneal carcinomatosis after colorectal cancer resection
High-quality population-based data on metachronous metastases of colorectal origin are rarely available in observational studies. Especially, data on metachronous peritoneal carcinomatosis (PC) are scarce as this was regarded as a disease only to be palliated until recent years. Van Gestel et al. found that approximately one out of five colorectal cancer patients who was diagnosed with metachronou...
Short-course preoperative radiotherapy in elderly rectal cancer patients
Elderly patients receiving pre-operative radiotherapy show a lower local recurrence rate. However, as incidence rates of local recurrent disease are low and incidence of postoperative complications is increased in irradiated patients, omitting preoperative radiotherapy may be suitable in elderly patients with additional risks for complications or early death. This conclusion can be read in a recen...
Incidence, treatment and survival of patients with peritoneal metastases
The prognosis of PM of unknown origin is extremely poor and did not improve over time, even though more chemotherapy was administered. Given the recent progress that has been achieved in selected patients presenting with PM, maximum efforts should be undertaken in order to diagnose the origin of PM as accurately as possible. Potentially effective treatment strategies should be further explored for...
Markedly increased incidence and improved survival of testicular cancer
The incidence of testicular cancer has increased sharply in the Netherlands in the period 1989-2009, with the largest increase in localized tumors. The nationwide population-based study of Verhoeven et al. furthermore showed that most patients received primary treatment according to the guidelines and that the five-year relative survival improved over time for most groups of stage and histology.
Peritoneal carcinomatosis of gastric origin
Until recently, peritoneal carcinomatosis (PC), in which malignant ascites forms in the peritoneum, was considered to be an untreatable condition. But new treatment options have raised hope for improved survival, as well as created a need to better understand risk factors and prevention. Here, analysis of data from the Eindhoven Cancer Registry from 1995-2011 reveals that more than one-third of pa...
Increased health care use among endometrial cancer survivors
Increasing numbers of endometrial cancer survivors place a high burden on the health care system, pressing the need to understand what affects health care use of these women. Dr. Nicole Ezendam and co-authors showed that endometrial cancer survivors use more health care than women in the general population. Age, education, comorbidity affected this health care use, while receiving radiotherapy of ...
Hospital volume and outcome after colorectal cancer surgery
In the southern Netherlands, the lowest volume hospitals deliver similar high quality surgical colorectal cancer care as the highest volume hospitals in terms of circumferential resection margins, anastomotic leakage and survival, also after adjustment for casemix. This conclusion can be read in a recent article of Felice van Erning and colleagues in European Journal of Surgical Oncology.
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